Nodal signaling: developmental roles and regulation
Top Cited Papers
- 15 March 2007
- journal article
- review article
- Published by The Company of Biologists in Development
- Vol. 134 (6) , 1023-1034
- https://doi.org/10.1242/dev.000166
Abstract
Nodal-related ligands of the transforming growth factor-beta (TGFβ)superfamily play central roles in patterning the early embryo during the induction of mesoderm and endoderm and the specification of left-right asymmetry. Additional roles for this pathway in the maintenance of embryonic stem cell pluripotency and in carcinogenesis have been uncovered more recently. Consistent with its crucial developmental functions, Nodal signaling is tightly regulated by diverse mechanisms including the control of ligand processing, utilization of co-receptors, expression of soluble antagonists, as well as positive- and negative-feedback activities.Keywords
This publication has 139 references indexed in Scilit:
- Smads orchestrate specific histone modifications and chromatin remodeling to activate transcriptionThe EMBO Journal, 2006
- Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressivenessNature Medicine, 2006
- PPM1A Functions as a Smad Phosphatase to Terminate TGFβ SignalingPublished by Elsevier ,2006
- Hematopoiesis Controlled by Distinct TIF1γ and Smad4 Branches of the TGFβ PathwayCell, 2006
- The zebrafish dorsal axis is apparent at the four-cell stageNature, 2005
- Zebrafish Dpr2 Inhibits Mesoderm Induction by Promoting Degradation of Nodal ReceptorsScience, 2004
- Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor CriptoGenes & Development, 2003
- Lefty Proteins Are Long-Range Inhibitors of Squint-Mediated Nodal SignalingCurrent Biology, 2002
- Diffusion of Nodal Signaling Activity in the Absence of the Feedback Inhibitor Lefty2Developmental Cell, 2001
- Zebrafish Nodal-Related Genes Are Implicated in Axial Patterning and Establishing Left–Right AsymmetryDevelopmental Biology, 1998