Current concepts and applications of coronary venous retroinfusion
- 1 November 2004
- journal article
- review article
- Published by Springer Nature in Basic Research in Cardiology
- Vol. 99 (6) , 373-381
- https://doi.org/10.1007/s00395-004-0486-3
Abstract
Retroinfusion of the coronary veins has gained attention for therapeutic approaches which target drugs, genes or cells to ischemic myocardium. Besides anatomy of the coronary venous system, the pressure flow relationship during retroinfusion and the efficacy of pressure-regulated selective retroinfusion for targeted delivery of drugs is reported. Moreover, we describe adenoviral and liposomal gene transfer into ischemic and nonischemic myocardium, outline studies in chronic ischemic preclinical models treated by retroinfusion of pro-angiogenic agents and discuss the impact of retroinfusion for cell-based regenerative therapy of the diseased myocardium.Keywords
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