Encephalomyelitis in Monkeys
- 9 June 1939
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 89 (2319) , 542-543
- https://doi.org/10.1126/science.89.2319.542
Abstract
When a massive dose of either eastern or western virus of equine encephalomyelitis is instilled intranasally into a young rhesus monkey, it will in most instances succumb to a fatal infection. Symptoms of the 2 forms of virus have been similar except that as in other animals the eastern has run a shorter course. "Dropping virus into the eye has not resulted in either disease or measurable antibodies. Eastern virus injected intralingually and western virus introduced by stomach tube have proved fatal, but we have not diseased healthy animals by keeping them caged with sick ones." Hyperimmune horse serum has provided passive protection against nasally instilled virus. Incomplete protection has been furnished by serum administered within 3 hrs. of infection. In numerous trials no beneficial effect has resulted from such a serum given at and after the time of first temp. rise, even when this serum was equivalent in amount to the injection of 500 cc. into a 150-lb. man. "Animals twice vaccinated with crude chick embryo vaccine have in all but one instance been completely protected against massive doses of intranasal virus. This vaccination has produced antibodies which were present in high titer after eastern, in lower titer after western vaccine injection.".This publication has 6 references indexed in Scilit:
- Recovery of the Virus of Equine Encephalomyelitis from the Brain of a ChildScience, 1938
- Recovery of Eastern Equine Encephalomyelitis Virus from Brain Tissue of Human Cases of Encephalitis in MassachusettsScience, 1938
- Human Encephalitis Caused by the Virus of the Eastern Variety of Equine EncephalomyelitisNew England Journal of Medicine, 1938
- The Ultracentrifugal Concentration of the Immunizing Principle from Tissues Diseased with Equine EncephalomyelitisScience, 1938
- Infection of the rhesus monkey (Macaca mulatta) and the guinea‐pig with the virus of equine encephalomyelitisThe Journal of Pathology and Bacteriology, 1936
- A Summary of Recent Studies on Equine Encephalomyelitis.Annals of Internal Medicine, 1932