A biochemical and morphological investigation of alkaline phosphatase and Ca+2‐ATPase during initial mineralization in chick embryonic tibia

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Abstract
Biochemical analysis of the enzymes alkaline phosphatase and Ca+2-ATPase in the membrane fraction obtained from chick embryonic tibias showed a positive correlation between the elevated activity of these two enzymes and the onset of mineralization. Histochemistry further showed an increased intensity of alkaline phosphatase at the time of the onset of mineralization. It seems that both of these enzymes are involved in the process of mineralization.