PSYCHOTIC BEHAVIOR AS THE INITIAL INDICATOR OF ADULT MYXEDEMA

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Abstract
Four cases are presented of psychosis associated with hypo-thyroidism. In 3 patients the psychiatric manifestations were the earliest presenting symptoms. In one case the mental change occurred shortly after myxedema developed. Serial eeg studies in two patients revealed a low voltage slow alpha activity which returned gradually to normal with the improvement of mental state and return to euthyroid condition. Treatment with desiccated thyroid produced complete relief in 2 cases within a few weeks, while the other 2 patients on thyroid slowed only partial recovery. The mental picture was not specific and included dementia, confusion, depression, hallucinations, ideas of persecution and hyperactive delirium.

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