Cytolytic effects of the complement cleavage product, C3a
Open Access
- 1 December 1976
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 34 (6) , 626-634
- https://doi.org/10.1038/bjc.1976.223
Abstract
Purified C3a, a cleavage product of the third component of complement,was incubated with various cell types of human and mouse origin. All the tumour cell types tested were lysed by low concentrations of C3a, whereas normal human lymphocytes were relatively resistant. No lysis was produced by C3 or C3b. The possible role of C3a in immunity against tumours is discussed.Keywords
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