The simplicity of complex MACs
- 1 November 1997
- journal article
- Published by Springer Nature in Nature Biotechnology
- Vol. 15 (12) , 1257-1259
- https://doi.org/10.1038/nbt1197-1257
Abstract
The development of mammalian artificial chromosomes (MACs) would be useful for biotechnology and biomediclne, including their use in functional genomics, transgenic animals and gene therapy. By analogy to large cloning systems in microorganisms, MACs may be engineered using endogenous chromosomal elements such as the yeast-based artificial chromosomes (YACs), or exogenous extra-chromosomal components derived from viruses and other cellular parasites such as the bacterial-based artificial chromosomes (BACs) and p1 artificial chromosomes (PACs).Keywords
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