Review article: β3‐adrenoceptor agonists—future anti‐inflammatory drugs for the gastrointestinal tract?
- 2 October 1996
- journal article
- review article
- Published by Wiley in Alimentary Pharmacology & Therapeutics
- Vol. 10 (6) , 859-863
- https://doi.org/10.1046/j.1365-2036.1996.71245000.x
Abstract
The beta 3-adrenoceptor is now a recognized sub-type of beta-adrenoceptor and is the principle adrenoceptor responsible for lipolysis in rat adipocytes. The receptor is also found in the gastrointestinal tract where beta 3-adrenoceptor agonists are both spasmolytic and potent inhibitors of experimental non-steroidal anti-inflammatory drug (NSAID)-induced gastric and small intestinal ulcers. There is evidence to suggest that the underlying mechanism of protection involves enhancement of mucosal blood flow, possibly as a result of relaxation of vascular and non-vascular smooth muscle. This review examines some possible therapeutic applications for beta 3-adrenoceptor agonists in ulcero-inflammatory disorders of the gastrointestinal tract where an altered blood flow state is a component of the underlying pathogenic process.Keywords
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