In vitro and in vivo antitumor activity of a novel immunomodulatory drug, leflunomide
- 1 November 1999
- journal article
- Published by Elsevier in Biochemical Pharmacology
- Vol. 58 (9) , 1405-1413
- https://doi.org/10.1016/s0006-2952(99)00228-2
Abstract
No abstract availableKeywords
This publication has 18 references indexed in Scilit:
- Leflunomide < Rec INN >Drugs of the Future, 1998
- From Bench Top to BedsideScience, 1997
- The Immunosuppressive Metabolite of Leflunomide Is a Potent Inhibitor of Human Dihydroorotate DehydrogenaseBiochemistry, 1996
- Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridineImmunology Letters, 1995
- Dihydroorotate Dehydrogenase Is a High Affinity Binding Protein for A77 1726 and Mediator of a Range of Biological Effects of the Immunomodulatory CompoundJournal of Biological Chemistry, 1995
- Leflunomide interferes with pyrimidine nucleotide biosynthesisInflammation Research, 1995
- Molecular genetics of human gliomaCurrent Opinion in Oncology, 1995
- Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomideFEBS Letters, 1993
- Tyrphostins. II. Heterocyclic and .alpha.-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinasesJournal of Medicinal Chemistry, 1991
- Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitorsJournal of Medicinal Chemistry, 1989