IL‐4 inhibits LPS‐, IL‐1β‐ and TNFα‐induced expression of tissue factor in endothelial cells and monocytes
- 21 September 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 310 (1) , 31-33
- https://doi.org/10.1016/0014-5793(92)81139-d
Abstract
Inflammatory mediators such as endotoxin, interleukin-1β(IL-1β) and tumor necrosis factors-α (TNF-α) dose-dependently increased the expression of tissue factor on the surface of cultured bovine aortic endothelial cells (ABAE), human umbilical vein endothelial cells (HUVEC) and human monocytes. In ABAE, endotoxin-, IL-1β- and TNFα-induced tissue factor expression was suppressed by interleukin-4 (IL-4) which also neutralized the pyrogenic effect of endotoxin in HUVEC and monocytes. IL-4 did not alter TNF-α-induced procoagulant changes in HUVEC and monocytes but strongly protected the monocyte surface against IL-1β-induced procoagulant changes.Keywords
This publication has 14 references indexed in Scilit:
- Heterogeneous regulation of constitutive thrombomodulin or inducible tissue-factor activities on the surface of human saphenous-vein endothelial cells in culture following stimulation by interleukin-1, tumour necrosis factor, thrombin or phorbol esterBiochemical Journal, 1991
- Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2.Proceedings of the National Academy of Sciences, 1989
- A novel microtiter plate assay for the quantitation of procoagulant activity on adherent monocytes, macrophage and endothelial cellsThrombosis Research, 1989
- Activity of pentosan polysulphate and derived compounds on vascular endothelial cell proliferation and migration induced by acidic and basic FGF in vitroBiochemical Pharmacology, 1988
- Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.Proceedings of the National Academy of Sciences, 1986
- Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity.Proceedings of the National Academy of Sciences, 1986
- Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells.The Journal of Experimental Medicine, 1984
- Cultured human endothelial cells generate tissue factor in response to endotoxin.Journal of Clinical Investigation, 1983
- Isolation of Lymphocytes, Granulocytes and MacrophagesScandinavian Journal of Immunology, 1976
- Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIAJournal of Clinical Investigation, 1973