Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse.
- 1 February 1968
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 59 (2) , 437-444
- https://doi.org/10.1073/pnas.59.2.437
Abstract
Four radiation-induced alleles at the albino locus of the mouse produce, in homozygotes, in addition to absence of pigmentation, abnormalities of thymus and kidneys and deficiency of glucose-6-phosphatase. The resulting hypogly-cemia accounts for death of newborn mice within a few hr. after birth. The mutations are chromosomal deficiencies including a genetic region which controls enzymes involved in melanin formation and in glycogen metabolism.Keywords
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