EFFECT OF TRIMETAPHAN ON HAEMODYNAMICS AND OXYGEN CONSUMPTION DURING HALOTHANE ANAESTHESIA IN MAN

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Abstract
Haemodynamic and metabolic observations have been carried out before, during, and after the administration of trimetaphan in six unpremedicated, paralyzed, hyperventilated patients during varicose vein operations and halothane anaesthesia. With trimetaphan, arterial pressure and stroke volume fell, cardiac output changed little, and oxygen uptake fell slightly. In the majority of cases, an increased pulse rate compensated for the reduced stroke volume. Myocardial contractility or distensibility, or both, were apparently altered since right atrial pressure was unchanged. Both calculated (mixed venous) and observed (right atrial) central venous oxygen saturations were fairly normal with little change during the trimetaphan infusion. The theoretical and clinical implications of these and comparable observations during anaesthesia with ether are discussed.

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