Diaspirins that crosslink .beta. chains of hemoglobin: bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate

2 October 1979

journal article
research article
Published by American Chemical Society (ACS) in Biochemistry

Vol. 18 (20) , 4265-4270
https://doi.org/10.1021/bi00587a001

Abstract

Two double-headed aspirins, bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate, were potent acylating agents of intracellular [human] Hb (A or S) in vitro. These reagents cross-linked .beta. chains of Hb, probably at the .beta. cleft. The modified Hb showed increased O2 affinities and reduced gelation or sickling tendencies.