Molecular Characterization of the Nur77 Orphan Steroid Receptor in Apoptosis

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Abstract
One of the in vitro model of programmed cell death is T cell receptor (TCR)-mediated apoptosis of immature T cells and T cell hybridomas. This form of apoptosis requires newly gene synthesis and may relate to negative selection during T cell development. Recently, an orphan steroid receptor Nur77 was found to be induced during TCR-mediated apoptosis. When introduced into T cells, a dominant negative or antisense Nur77 construct can block the apoptosis process. Various inhibitors of TCR-mediated apoptosis, including cyclosporin A down-regulate the Nur77 DNA binding activity. Thus, the Nur77 protein family may play a crucial role during T cell apoptosis.

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