Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

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Abstract
Through a PCR‐based differential screening method, cyclin G was identified as a novel transcriptional target of the p53 tumor suppressor gene product. In both a mouse p53 temperature‐sensitive leukemic cell line and mouse embryonic fibroblasts (MEF) after gamma‐irradiation, cyclin G mRNA was rapidly induced. MEF from a p53‐deficient mouse expressed cyclin G at a level > 10‐fold lower than that from a wild‐type mouse. Using a DNA binding assay, a specific p53 binding site was identified upstream from the cyclin G gene, which functioned as a p53‐dependent cis‐acting element in a transient transfection assay. These results suggest that cyclin G might participate in a p53‐mediated pathway to prevent tumorigenesis.