Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke
- 26 June 2001
- journal article
- case report
- Published by Wolters Kluwer Health in Neurology
- Vol. 56 (12) , 1751-1753
- https://doi.org/10.1212/wnl.56.12.1751
Abstract
Idiopathic narcolepsy usually results from a loss of the hypothalamic neuropeptide orexin (hypocretin), but the cause of secondary narcolepsy resulting from focal brain lesions is unknown. The authors describe a young man who developed narcolepsy after a large hypothalamic stroke. His lesion included much of the hypothalamic region in which orexin is produced, and his CSF concentration of orexin was low. The authors hypothesize that a loss of orexin neurons or their relevant targets may be the specific neuropathology causing this and many other cases of secondary narcolepsy.Keywords
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