Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats
- 1 February 1986
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 111 (1) , 71-74
- https://doi.org/10.1007/bf00402780
Abstract
Four histamine antagonists, methapyrilene, thenyldiamine, mepyramine and pyribenzamine were tested for carcinogenicity in rats by continuous application in drinking water. Only methapyrilene displayed significant carcinogenic effects, inducing liver tumors in a dose-related pattern. Analogues not containing a thiophene ring (mepyramine, pyribenzamine) did not exhibit neoplastic effects under the experimental conditions.This publication has 9 references indexed in Scilit:
- Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 ratsFood and Chemical Toxicology, 1984
- Early stages of chemically induced liver carcinogenesis by oral administration of the antihistaminic methapyrilene hydrochlorideZeitschrift für Krebsforschung und Klinische Onkologie, 1983
- Inability of methapyrilene to induce sister chromatid exchanges in vitro and in vivo.1982
- The effects of methapyrilene hydrochloride on hepatocarcinogenicity and pentobarbital-induced sleeping time in rats and miceToxicology and Applied Pharmacology, 1982
- DNA damage induced by the antihistaminic drug methapyrilene hydrochlorideMutation Research Letters, 1982
- Distribution of the liver carcinogen methapyrilene in fischer rats and its interaction with macromoleculesZeitschrift für Krebsforschung und Klinische Onkologie, 1982
- Liver Tumors Induced in Rats by Oral Administration of the Antihistaminic Methapyrilene HydrochlorideScience, 1980
- Nitrosation and mutagenicity of some amine drugsToxicology and Applied Pharmacology, 1980
- Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments.1980