QUANTITATIVE STUDIES ON HISTOCOMPATIBILITY ANTIGENS OF THE MOUSE*

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Abstract
A substantial fraction of the H-2 determined isoantigens of the C57BL/6 mouse have been found to be closely associated with the acid phosphatase-rich lysosomal fraction of the cell. These antigens occur in high concentration it organs of the RES and undergo marked increase during "activation" of this system. A hypothesis is proposed that these antigens are especially abundant in a system of organelles which mediate the secretory and phagocytic functions of various cells. Antigen was detectable by a serologic technique in the tissues of newborn animals. On the first day of life the antigen concentration of the liver exceeded that of the spleen, but the more rapid increase in splenic activity resulted in a reversal of these relative specific activities on the 5th-7th days. Adult levels were not attained until the 28th day of life.