THALLIUM SCINTIGRAPHY IN EXPERIMENTAL TOXIC PULMONARY-EDEMA - RELATIONSHIP TO EXTRAVASCULAR PULMONARY FLUID

  • 1 January 1984
    • journal article
    • research article
    • Vol. 25  (5) , 581-591
Abstract
Pulmonary fluid volumes (PBV = lung blood volume; EVLW = extravascular lung water) were examined to define the effects of oleic acid injury and then to examine the relationship between edema formation and accumulation of pulmonary Tl. In 6 dogs, pulmonary fluid compartments were monitored during the induction of pulmonary injury by oleic acid (0.15 ml/kg i.v.). By 30 min after the injection, EVLW had doubled (P < 0.01); it continued to increase slowly for 180 min, whereas PBV declined. In 6 anesthetized dogs, similar measurements were made in an identical preparation and compared pulmonary fluid volumes with pulmonary counts derived from sequential Tl (1-1.3 mCi) scintigrams obtained after the injection of oleic acid (0.12-0.15 ml/kg). Measures of EVLW and PBV were obtained sequentially along with Tl scintigrams. There was a linear relationship between EVLW and pulmonary counts alone, or when pulmonary counts were normalized to myocardial activity. Sequential Tl scintigrams provide useful information about the degree of change of EVLW over time in a model of noncardiogenic pulmonary edema.

This publication has 1 reference indexed in Scilit: