LOWERING OF KININOGEN IN RAT BLOOD BY ADRENALINE AND ITS INHIBITION BY SYMPATHOLYTIC AGENTS, HEPARIN AND ASPIRIN

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Abstract
1 (–)-Adrenaline lowered the kininogen content and transitorily elevated the fibrinolytic activity of plasma following intravenous injection into the rat. Its effect on kininogen increased when administered by intravenous infusion. 2 Although less effective, (–)-noradrenaline had a similar action to adrenaline; (±)-isoprenaline was inactive and failed to inhibit the effect of adrenaline. 3 The effect of adrenaline on kininogen could be reproduced in vitro by incubation of whole blood, but not cell-free plasma, with the catecholamine for 5 min at 37° C. 4 Propranolol or phenoxybenzamine, as well as heparin or acetylsalicylic acid (aspirin), blocked the reduction of rat blood kininogen by adrenaline in vivo and in vitro.