Magnesium Pemoline: Lack of Facilitation in Human Learning, Memory, and Performance Tests

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Abstract
Either a placebo or 25 or 37.5 mg of magnesium pemoline was administered on a double-blind basis to three intelligence-matched groups of normal, adult males. Learning and 24-hr. retention tests included verbal learning, motor learning, and classical conditioning. Short-term memory tests were administered through both the visual and auditory modalities. Arm-hand steadiness and visual reaction time performance tests were included. The only measures revealing significant group differences showed the performance of subjects given pemoline was inferior to that of subjects given a placebo.