PcrV Immunization Enhances Survival of Burned Pseudomonas aeruginosa -Infected Mice
Open Access
- 1 September 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (9) , 5908-5910
- https://doi.org/10.1128/iai.69.9.5908-5910.2001
Abstract
Burned Pseudomonas aeruginosa -infected mice immunized against PcrV, a type III virulence system translocating protein, showed significantly enhanced survival compared to controls. Survival was non-O serotype specific and correlated with a reduced systemic microbial load. Infection with a high-level toxin A-producing strain required supplemental antitoxin treatment to enhance survival.Keywords
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