Cellular immune responses to HIV
Top Cited Papers
- 1 April 2001
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 410 (6831) , 980-987
- https://doi.org/10.1038/35073658
Abstract
The cellular immune response to the human immunodeficiency virus, mediated by T lymphocytes, seems strong but fails to control the infection completely. In most virus infections, T cells either eliminate the virus or suppress it indefinitely as a harmless, persisting infection. But the human immunodeficiency virus undermines this control by infecting key immune cells, thereby impairing the response of both the infected CD4+ T cells and the uninfected CD8+ T cells. The failure of the latter to function efficiently facilitates the escape of virus from immune control and the collapse of the whole immune system.Keywords
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