THE UNIT OPERATIONS APPROACH APPLIED TO THE SYNTHESIS OF [1-C-11]2-DEOXY-D-GLUCOSE FOR ROUTINE CLINICAL-APPLICATIONS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 23  (8) , 739-744
Abstract
An approach to the design of remote semiautomated chemical processing systems was developed and tested in > 750 production runs. This design stresses the idea of unit operations, which allows maximum flexibility while maintaining the highest possible standards regarding safety, reliability, efficiency and practicality. Application of this approach resulted in the development of a simple and reliable remote semiautomated synthesis system for the routine production of [1-11C]2-deoxy-D-glucose. Use of this system results in the preparation of a sterile, pyrogen-free product suitable for human injection after a synthesis time of 50 min, with radiochemical purity of > 98% and yields (25-30%) permitting quantitative measurements by positron computed tomography.

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