PIP2Is a Necessary Cofactor for Ion Channel Function:Howand Why?
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- 1 June 2008
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biophysics
- Vol. 37 (1) , 175-195
- https://doi.org/10.1146/annurev.biophys.37.032807.125859
Abstract
Phosphatidylinositol 4,5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet of plasma membranes. Many plasma membrane ion channels and ion transporters require PIP2 to function and can be turned off by signaling pathways that deplete PIP2. This review discusses the dependence of ion channels on phosphoinositides and considers possible mechanisms by which PIP2 and analogues regulate ion channel activity.Keywords
This publication has 103 references indexed in Scilit:
- Crystal structure of a Kir3.1-prokaryotic Kir channel chimeraThe EMBO Journal, 2007
- Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysisThe EMBO Journal, 2007
- Regulation of KCNQ channels by manipulation of phosphoinositidesThe Journal of Physiology, 2007
- Dissection of the components for PIP 2 activation and thermosensation in TRP channelsProceedings of the National Academy of Sciences, 2007
- Integration of Phosphoinositide- and Calmodulin-Mediated Regulation of TRPC6Molecular Cell, 2007
- Neuronal two‐pore‐domain potassium channels and their regulation by G protein‐coupled receptorsThe Journal of Physiology, 2007
- Regulation of Gating and Rundown of HCN Hyperpolarization-activated Channels by Exogenous and Endogenous PIP2The Journal of general physiology, 2006
- Phosphoinositide 3-Kinase Binds to TRPV1 and Mediates NGF-stimulated TRPV1 Trafficking to the Plasma MembraneThe Journal of general physiology, 2006
- A single amino acid mutation attenuates rundown of voltage-gated calcium channelsFEBS Letters, 2006
- Intracellular Ca 2+ and the phospholipid PIP 2 regulate the taste transduction ion channel TRPM5Proceedings of the National Academy of Sciences, 2003