Effects of Adrenergic P-Blockers and a Membrane Stabilizing Agent on Ouabain-Induced Cardiac Arrhythmias in Anaesthetized Guinea Pigs
- 13 March 2009
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 45 (2) , 102-106
- https://doi.org/10.1111/j.1600-0773.1979.tb02368.x
Abstract
The antiarrhythmic effects of dl-propranolol, d-propranolol, metoprolol and lidocaine against ouabain-induced cardiac arrhythmias were studied. Apparently contrary to findings in the dog, the effects of the adrenergic .beta.-blockers against ouabain-arrhythmias in guinea pigs were due to .beta.-blocking activity and not the membrane-stabilizing activity of the compounds. The cardioselective .beta.-blocker metoprolol was more or equally effective as dl-propranolol against ouabain-induced arrhythmias in guinea pigs.Keywords
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