Toxic Epidermal Necrolysis (Scalded Skin Syndrome)

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Abstract
Two cases with the characteristic clinical picture of toxic epidermal necrolysis were presented. Unlike a large number of the reported cases, their courses were benign and of short duration. The patients survived without residua. Recognition of this ill-defined syndrome is based on the fact that the patient presents with bullous lesions which closely resemble those seen after scalding. A possible explanation for the absence of Nikolsky''s sign in the two patients constituting this report is given. The etiologic agent of the disease has not been discovered. Although steroids, antibodies and antihistaminics have been used for therapy, it seems that the disease is most probably self- limited and the prognosis unpredictable. It is suggested that the diagnosis be considered when history, clinical picture, and laboratory studies fail to classify bullous lesions into the well-known dermatologic conditions which present with this configuration of lesions. Further confirmation can only be secured through biopsy.
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