The influence on thyroid function of two iodine-containing radiological contrast media

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Abstract
The effects of 2 iodine-containing radiological contrast media (ioxaglate and diatrizoate) on plasma iodide, thyroid hormones and TSH were established in a group of 20 subjects (8 females, 12 males). The following were evaluated 2, 8 and 30 days after administration of the drugs: plasma iodide, T4 [thyroxine], T3 [triiodothyronine], r[reverse]T3, free T4 index, TSH before and after TRH (250 .mu.g i.v.). 131I uptake was measured before the media were given and 30 days afterwards. The results were compared at the different times during the investigation using Wilcoxon''s signed ranking test for non-parametric variables. Plasma iodide was above the normal range 2-8 days after ioxaglate and 2-8 and 30 days after diatrizoate. After ixoaglate, rT3 was increased at 8 days and T3 at 30 days. 131I uptake remained low after the 30th day. After diatrizoate, T4 was decreased on the 2nd day and free T4 index was low on the 8th and 30th day. All figures represent statistically significant but nevertheless minor variations of the initial value of each parameter. Although ioxaglate and diatrizoate lead to variations in plasma thyroid hormone levels, they are of little importance.