Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin β is the true human homologue of rat thymosin β15
Open Access
- 12 September 2007
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 581 (25) , 4809-4815
- https://doi.org/10.1016/j.febslet.2007.09.003
Abstract
A peptide with a sequence identical to rat thymosin β(Tb)15 was reported to be upregulated in human prostate cancer. However, in this report we provide evidence that TbNB, initially identified in human neuroblastoma, is the only Tb isoform upregulated in human prostate cancer and that the Tb15 sequence is not present herein. In addition, we demonstrate that human TbNB has a higher affinity for actin in comparison to Tb4 and promotes cell migration. In combination, this experimentally validates TbNB as functional homologue of rat Tb15 in the human organism and clarifies the current composition of the human Tb family.Keywords
This publication has 26 references indexed in Scilit:
- Thymosin β‐NB Is the Human Isoform of Rat Thymosin β15Annals of the New York Academy of Sciences, 2007
- Activation of the Thromboxane A2 Pathway in Human Prostate Cancer Correlates with Tumor Gleason Score and Pathologic StageEuropean Urology, 2006
- Anti-apoptotic function of thymosin-β in developing chick spinal motoneuronsBiochemical and Biophysical Research Communications, 2006
- Effect of thymosin β15 on the branching of developing neuronsBiochemical and Biophysical Research Communications, 2005
- Structural basis of actin sequestration by thymosin-β4: implications for WH2 proteinsThe EMBO Journal, 2004
- Coupling of Folding and Binding of Thymosin β4 upon Interaction with Monomeric Actin Monitored by Nuclear Magnetic ResonanceJournal of Biological Chemistry, 2004
- Overexpression of the thymosin β-4 gene is associated with malignant progression of SW480 colon cancer cellsOncogene, 2003
- Chemotherapeutic drugs change actin skeleton organization and the expression of β-thymosins in human breast cancer cellsZeitschrift für Krebsforschung und Klinische Onkologie, 2002
- β-Thymosins, small acidic peptides with multiple functionsThe International Journal of Biochemistry & Cell Biology, 2001
- Thymosin β4 Binds Actin in an Extended Conformation and Contacts both the Barbed and Pointed EndsBiochemistry, 1997