The activation of fatty acid oxidation by kidney and liver mitochondria

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Abstract
The oxidation of octanoate by rat-liver mitochondria may be activated by ATP or by a system generating ATP. Rabbit-kidney and rabbit liver mitochondria are unable to activate octanoate oxidation in the presence of ATP and require the co-oxidation of an intermediate of the citric acid cycle. The different requirements of the 3 tissues are discussed. The action of 2,4-dini-trophenol on fatty acid oxidation is shown to be due to the inhibition of ATP synthesis. Reversal of this inhibition by ATP was demonstrated. The activation of fluoroacetate was studied. 2,4-Dinitrophenol prevents its activation and this effect can be suppressed by ATP. The effect of fluoroacetate on fatty acid oxidation is due solely to its inhibition of the citric acid cycle.