Differential regulation of interleukin‐12 p40 and p35 induction via Erk mitogen‐activated protein kinase‐dependent and ‐independent mechanisms and the implications for bioactive IL‐12 and IL‐23 responses
Open Access
- 16 June 2003
- journal article
- research article
- Published by Wiley in Immunology
- Vol. 109 (3) , 415-425
- https://doi.org/10.1046/j.1365-2567.2003.01689.x
Abstract
Bioactive interleukin (IL)-12 is a 70 000-molecular weight (MW) heterodimeric cytokine comprising p40 and p35 chains. However, p40 can also form homodimers that antagonize bioactive IL-12 or heterodi...Keywords
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