Acoustic, fluorescent diagnosis of malignant lesions using HAT-D01 and ATX-S10

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Abstract
We have synthesized approximately 700 kinds of porphyrin derivatives and studied their side chain structures and affinities for tumor tissues. On the basis of these studies, a tumor localizing photo-chlorine photosensitizer named ATX-S10 has been synthesized for PDT and fluorescent diagnosis of malignant lesions. A non-photosensitive fluorescent diagnostic agent named HAT-D01 has also been synthesized. Both derivatives have the fluorescence near 680 nm that is far from the auto-fluorescence of biological tissue. For detection of tumor tissue, we have developed a new device that can pick up 670 - 680 nm fluorescence selectively and convert the intensity of fluorescence to the sound. By using this simple new device after ATX- S10, HAT-D01 administration we could detect well the malignant lesions.

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