Mise en evidence de l'oxydation par le rat d'un hydrocarbure naphtenique, le dodecylcyclohexane

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Abstract
Naphthenic hydrocarbons, mainly of fossil origin, are widespread in our environment, and contaminate the food chains; they are also used as food additives. Their fate in mammals is unknown, except for the fact that they are absorbed and accumulate in tissues. Only a few microorganisms have been shown capable of oxidising n‐alkyl substituted cycloparaffins. In this study, dodecylcyclohexane has been chosen as a typical monocycloparaffin, and has been administered orally to rats. The GLC and GLC—MS analysis of the methylesters of body and hepatic fatty acids led to the identification of cyclohexyldodecanoïc and its decanoïc and octanoïc homologs. The alkyl chain undergoes a terminal oxidation followed by the classical β‐oxidation process. After administration of one 200 mg dose, or incorporation of 0.1% of the cycloparaffin in the diet for 2 months, these acids were found at low levels in neutral lipids and phospholipids. Their subsequent metabolic pathway and their possible interaction with the biochemical mechanisms involving phospholipids are under investigation.

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