Causative role of oxyradicals in myocardial stunning: A proven hypothesis
- 3 July 1998
- journal article
- research article
- Published by Springer Nature in Basic Research in Cardiology
- Vol. 93 (3) , 156-162
- https://doi.org/10.1007/s003950050079
Abstract
Whether or not ROS are the actual initiator or a downstream mediator of stunning, the theory that they play a major causative role in this phenomenon is now a proven hypothesis. ROS play a prominent role in multiple forms of stunning. Furthermore, the role of ROS is prominent not only in open-chest models but also in conscious animal preparations. The major challenge for future studies will be to identify the specific molecular targets of ROS-mediated damage and to decipher the pathways whereby ROS and calcium interact in the genesis of myocardial stunning.Keywords
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