NONRANDOM CENTROMERE DIVISION - ANALYSIS OF G-BANDED HUMAN-CHROMOSOMES

  • 1 January 1981
    • journal article
    • research article
    • Vol. 32  (1) , 55-59
Abstract
The distribution by individual chromosomes of early centromere divisions was investigated in 2 series of G-banded lymphocyte culture preparations. Photographs of mitoses of routinely karyotyped 201 healthy persons were analyzed. In a prospective study, 48 and 72 h cultures of 12 girl infants were examined. Both series confirm a non-randomness of centromere separation which seems to be independent of sex and technical factors. The earliest dividing chromosomes were no. 18, 2, 5, 12 and X, in that order; the acrocentrics were the last to separate. The investigation of asynchronous division may be interesting from the point of view of mechanism of non-disjunction and of testing mutagenicity.