Growth, toxigenicity and virulence ofPseudomonas aeruginosa

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Abstract
The virulence ofPseudomonas aeruginosaappears to depend on both its ability to grow in the serum of animals and its ability to produce various types of extra-cellular toxins. No strain ofPs. aeruginosalacking either of these qualifications was ever found to be virulent to animals.The ability of various sera of animals to inhibit growth ofPs. aeruginosaappears to depend largely on their content of specific antibodies to each serological type of the surface antigens (the slime layer) and, therefore, susceptibility of animals to the infections ofPs. aeruginosa, even within one species, varies considerably from one individual to another.This work was supported by a research career development award of the U.S. Public Health Service to the senior author (GM-K3–15).

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