PRELIMINARY EVIDENCE OF NATURAL-RESISTANCE TO MYCOBACTERIUM-BOVIS (BCG) IN LEPROMATOUS LEPROSY

  • 1 January 1984
    • journal article
    • research article
    • Vol. 52  (2) , 140-146
Abstract
An assay system was developed based on radiometric quantification of 3H uracil incorporation into viable BCG in the absence or presence of blood monocytes in cultures from untreated lepromatous (LL) or tuberculoid (TT) leprosy patients. 3H Uracil incorporation into BCG was inhibited when the bacilli were cultivated in the presence of blood-derived macrophages in culture for 4 days; inhibition was always greater with macrophages harvested from LL patients compared to TT patients. The reasons for such an observed difference in humans are discussed according to knowledge obtained in murine models of mycobacterial infections.

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