Induction, repair and biological relevance of radiation-induced DNA lesions in eukaryotic cells
- 1 December 1990
- journal article
- review article
- Published by Springer Nature in Radiation and Environmental Biophysics
- Vol. 29 (4) , 273-292
- https://doi.org/10.1007/bf01210408
Abstract
Summary This report summarizes data on the induction, repair and biological relevance of five types of radiation-induced DNA lesions for which repair kinetic studies have been performed in eukaryotic cells by various laboratories. These lesions are: DNA-protein crosslinks, base damage, single-strand breaks, double-strand breaks and bulky lesions (clustered base damage in the nm-range). The influence of various factors, such as oxia/anoxia, linear energy transfer of the radiation used, incubation medium, cell cycle stage, thiol content, hyperthermia, on the induction and repair of these lesions is described. Radiation-sensitive cell lines are also included.Keywords
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