δ Opioid receptor mediates phospholipase C activation via Gi in Xenopus oocytes
- 12 November 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 333 (3) , 311-314
- https://doi.org/10.1016/0014-5793(93)80677-m
Abstract
Cloned mouse δ‐subtype opioid receptor (DOR1) was expressed in Xenopus oocytes to study the signal transduction. Opioid δ‐agonists evoked a calcium‐dependent chloride current in oocytes injected with mRNA derived from DOR1, together with that from the α subunit of Gi1. The δ‐agonist‐induced current was blocked by naltrindol, a δ‐specific antagonist. The δ‐agonist evoked no or very weak currents in oocytes with the α subunit of Gq or Go. These findings indicate the functional coupling between the opioid δ‐receptor and phospholipase C through an activation of Gi.Keywords
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