Effects of Cisapride on Oesophageal Transit of Solids in Patients with Progressive Systemic Sclerosis
- 1 February 2002
- journal article
- clinical trial
- Published by Springer Nature in Clinical Rheumatology
- Vol. 21 (1) , 43-45
- https://doi.org/10.1007/s100670200010
Abstract
In most patients with progressive systemic sclerosis (PSS) the oesophagus is affected. Reflux symptoms are most frequent, whilst dysphagia also occurs. Cisapride, a prokinetic agent, may enhance motility along the gastrointestinal tract. The effects of cisapride on oesophageal transit were evaluated in 12 PSS patient using a solid-phase radionuclide oesophageal transit study. Each PSS patient was given cisapride 10 mg or placebo orally three times a day in a random, double-blind, crossover fashion. The results show that cisapride does not seem to have any impact on oesophageal transit in patients with PSS.Keywords
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