Extended wear of contact lenses can compromise corneal epithelial adhesion

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Abstract
The wound healing response of the cat corneal epithelium was examined to provide information on the effect of extended wear contact lenses on epithelial integrity. During the wounding procedure, a loss of epitheial adhesion in the lens wearing eye relative to the control eye was noted. This indicates a loss of epithelium-to-basement membrane adhesion which may be a result of contact-lens induced hypoxia.