Topical tretinoin therapy and oral lichen planus

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Abstract
The treatment of severe forms of oral lichen planus is still relatively unsatisfactory. In this controlled study, 0.1% tretinoin in an adhesive base was used in 23 patients. Fifteen other control patients were similarly treated with the vehicle alone. In the tretinoin-treated group, 71% of the atrophic-erosive lesions improved while 29% improved from the vehicle (P < 0.05). Reticular-plaque lesions improved in 74% from tretinoin and in 15% from the vehicle (P < 0.001). Irritation from tretinoin occurs and thorough usage information is mandatory.

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