Glucagon secretory responses to insulin-induced hypoglycemia and arginine in streptozotocin-induced diabetic dogs.

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Abstract
To clarify whether the reactivity of .alpha.-cells is regulated by .beta. cell function in the pancreas, plasma glucagon (IRG) responses to insulin-induced hypoglycemia and to arginine infusion were evaluated in streptozotocin (STZ; total 40 mg/kg) treated and control dogs. There was no significant rise in plasma IRG levels during the insulin-induced hypoglycemia in the STZ-treated dogs. In contrast, arginine enhanced the IRG secretion from the pancreas to a similar extent in the 2 groups. This was deduced from the difference between IRG levels in the pancreaticoduodenal and peripheral veins. Neither i.v. glucose nor arginine infusion resulted in a significant rise in plasma insulin (IRI) levels in the STZ-treated dogs. IRI content in the pancreas of STZ-treated dogs was significantly reduced to 5% below the levels in the control dogs. The IRG content for control and STZ-treated dogs did not differ. While the responsiveness of .alpha. cells to hypoglycemia may depend on the secretory capacity of .beta. cells, such is not the case with arginine.