Electrical Responses of Peritubular Membrane to Cationic Substitutions in Necturus

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Abstract
Eight cations were reversibly and isosmotically substituted for sodium (45 mM) in peritubular circulation of the proximal tubule of the doubly perfused Necturus kidney. Li, choline and tetramethylammonium produced small shifts in peritubular potential difference with no change in conductance. Tris- and tetraethylammonium depolarized the membrane by about 10 mV without affecting its conductance. Rb and Cs produced a decrease of membrane permeability to potassium. Potassium for sodium substitution depolarized the membrane (3.1 mV) and increased its conductance. It is concluded that none among the cations tested may be considered as readily less permeant than sodium across the peritubular membrane.

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