A new synthesis of thiazolo[3,2‐a] pyrimidinones
- 1 December 1967
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 4 (4) , 577-581
- https://doi.org/10.1002/jhet.5570040419
Abstract
5H‐Thiazolo[3,2‐a]pyrimidin‐5‐ones (V) have been prepared by S‐alkylation of 6‐methyl‐2‐thiouracil (Ib) with bromoacetone or bromoacetophenone followed by cyclization in sulfuric acid. By the same series of reactions, 2‐thiouracil (Ia) gave rise to 7H‐thiazolo[3,2‐a]pyrimidin‐7‐ones (VI). The properties and structures of the intermediates and products are discussed.Keywords
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