Relaxant and β2-adrenoceptor blocking activities of labetalol, dilevalol, amosulalol and KF-4317 on the rat isolated aorta
- 1 November 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 40 (11) , 812-815
- https://doi.org/10.1111/j.2042-7158.1988.tb05180.x
Abstract
The KCl-contracted rat aorta is relaxed by labetalol, dilevalol, amosulalol and KF-4317. These relaxations are not reversed by ICI 118,551 at 10−6 M and, therefore, are not due to β-adrenoceptor agonism. At 10−7 M, labetalol, dilevalol, amosulalol and KF-4317 were β2-adrenoceptor antagonists as they inhibited the relaxant responses of rat aorta to procaterol.This publication has 5 references indexed in Scilit:
- Amosulalol, a combined alpha and beta adrenoceptor antagonist: Kinetics after intravenous and oral dosesClinical Pharmacology & Therapeutics, 1984
- β-Adrenoceptor antagonistsPublished by Elsevier ,1984
- THE α‐ AND β‐ADRENOCEPTOR BLOCKING POTENCIES OF LABETALOL AND ITS INDIVIDUAL STEREOISOMERS IN ANAESTHETIZED DOGS AND IN ISOLATED TISSUESBritish Journal of Pharmacology, 1982
- DIRECT VASODILATATION BY LABETALOL IN ANAESTHETIZED DOGSBritish Journal of Pharmacology, 1980
- Evidence that ICI 118, 551 is a potent, highly beta2-selective adrenoceptor antagonist and can be used to characterize beta-adrenoceptor populations in tissuesLife Sciences, 1980