Gene-Environment Interaction in Alzheimer’s Disease:A Potential Role for Cholesterol
- 26 August 1998
- journal article
- review article
- Published by S. Karger AG in Neuroepidemiology
- Vol. 17 (5) , 225-232
- https://doi.org/10.1159/000026175
Abstract
Alzheimer’s disease is probably a complex disease caused by an interaction of multiple environmental and genetic factors. Genetic defects include ‘causative’ genes which are rare and a ‘susceptibility’ gene (σ4 allele of apolipoprotein E) which is more common in cases. Recent research suggests that environmental factors may interact with a genetic predisposition to modify the risk of Alzheimer’s disease. An interaction between serum cholesterol levels and σ4 genotype is proposed. The evidence for this gene-environment interaction is discussed.Keywords
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