Levamisole Is Inferior to Placebo in the Hyperimmunoglobulin E Recurrent-Infection (Job's) Syndrome

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Abstract
THE hyperimmunoglobulin E recurrent-infection syndrome (HIE), also known as Job's syndrome, is a disorder of unknown cause characterized by high levels of circulating IgE, a leukocyte chemotactic defect, and recurrent skin and sinopulmonary bacterial infections.1 2 3 4 These patients also frequently have eczematoid skin rashes, eosinophilia, and peculiarly "cold" skin abscesses with little surrounding inflammation. There is evidence that the syndrome has a familial pattern of incidence and may be inherited.5 Several reports describe treatment of patients with HIE with such agents as ascorbic acid,6 transfer factor,7 cimetidine,8 and levamisole,9 10 11 12 with various degrees of success.The immunopotentiating drug levamisole has been found . . .