Effect of Carbutamide on Serum Inorganic Phosphate

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Abstract
In view of the fact that insulin produces a decrease in serum inorganic phosphate, the possibility was explored that carbutamide could have this effect. In normal trained dogs carbutamide was given by vein (20% solution of the Na salt; 0.25 g/kg) and blood samples taken before and at 15, 30, 45, 60 and 120 minutes. The blood sugar showed the usual drop; serum inorganic phosphate did not decrease significantly. On the contrary, insulin or glucose showed a definite effect on serum phosphate. It is assumed that carbutamide does not act by an extra-insulin secretion or that its gradual action allows for correction of the effect on serum inorganic phosphate by homeostatic mechanisms. It may be possible that the drug has some inhibitory effect on phos-phorylation processes.