Successful treatment of invasive aspergillosis complicating prolonged treatment‐related neutropenia in acute myelogenous leukemia with amphotericin B lipid complex

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Abstract
Herein we report the successful treatment of invasive aspergillosis with the liposomal amphotericin B (AMB) formulation, Amphotericin B Lipid Complex (ABLC™). This investigational compound was employed in a 50-year-old patient with acute myelomonocytic leukemia complicated by prolonged, treatment-induced granulocytopenia and documented Aspergillus flavus sinusitis with signs of disseminated aspergillosis. The patient demonstrated radiographic signs of pulmonary aspergillosis and biochemical signs of hepatic involvement that were resistant to a 23 day course of conventional AMB (Fungizone®) therapy. Following therapy with ABLC™ her fever abated, her chest X-ray findings improved, and her hepatic function tests improved with eventual resolution.